Hospices Civils de Lyon
Hepatology department at the Croix-Rousse Hospital (Groupement Hospitalier Nord)
The hepatology department is lead by Pr Fabien Zoulim. The team comprises 5 university hospital physicians, 11 hospital physicians and non medical staff (nurses, care assistant, secretaries).
The service can accommodate up to 59 patients in conventional hospitalization and has an intense outpatient activity (consultation, day hospitalization, endoscopy).
The department of hepatology is a reference center in the management of all liver diseases and their complications. He is particularly expert for viral hepatitis B and C. The service is also recognized as a reference center for the diagnosis and treatment of liver cancer and for liver transplantation (medical follow-up before and after the transplant). In addition, the service has developed a competence for the management of addictions to alcohol and illicit substances by setting up a specialized consultation and a center dedicated to the care, support and prevention of addictions. The department coordinates an original therapeutic education program that supports new treatments for liver diseases. The hepatology department has also developed a clinical research activity visible at the highest international level with the support of the Clinical Research Center of the North Hospital Group. This activity gives him access to innovative treatments for all liver diseases.
Institute of Infectious Agents - Centre de Biologie du Groupement Hospitalier Nord (GHN)
Launched in 2012, the project to bring together all the microbiology laboratories of the CHU de Lyon on the site of the Croix Rousse hospital was launched in 2017. This project led to the creation of an Institute of Infectious Agents (IAI) in an existing building, reconfigured to accommodate all disciplines of microbiology. This institute is one of the two largest microbiology laboratories of CHU in France (the other being that of Marseille), gathering about 200 biologists and technicians. It provides microbiological management 24h / 24, 7 days / 7 (model 24-7) for all the Hospices Civils de Lyon (HCL), the Center Léon Bérard (CLB), and the Institute of Hematology and Pediatric Oncology (IHOPe), thanks to an automated bacteriology platform, an infectious serology platform, a molecular biology platform, a regional mycobacteria diagnostic unit, a conventional virology unit and a parasitology-mycology unit except automation and finally a consultation unit. It also houses 4 National Reference Centers for Communicable Diseases (Influenza, Enteroviruses, Staphylococci, Legionella) and a Biological Resource Center (CRB). It is the site of RHU IDBIORIV labeled in 2019 for a project to develop a bacterial identification technology and determination of antibiotic resistance by mass spectrometry in less than one hour.
Clinical Research Center (CRC) of the North Hospital Group
The Clinical Research Center (CRC) is located at the Croix-Rousse hospital (North Hospital Group), as close as possible to the investigators, the health care teams and the patients. The CRC is part of the support structures of the Department of Clinical Research and Innovation at Hospices Civils de Lyon. It is involved in many medical and surgical topics of the North Hospital Group (gynecology, oncology, ENT, pneumology, internal medicine) with a predominance for HIV, hepatology (virus, cancer, NASH*, liver transplantation, other liver diseases).
The CRC is headed by Professor Fabien Zoulim, who is in charge of the scientific responsibility. At the operational level, a coordinating physician, Dr. Marianne Maynard-Muet and an assistant pharmacist, Ms. Corinne Brochier provide daily animation and control of the CRC. The CRC team is composed of 7 project managers including 1 data-manager, 11 clinical research assistants (CRA), 2 logistic specialists, 1 methodologist-statistician and 1 clinical research physician. The CRC provides support for investigation tasks and setting up of projects for investigators wishing to conduct clinical research studies. The CRC can intervene at the request of the investigator from the drafting phase of the project through the response to invitations to tender, writing the study documents (protocol, case report form, information sheet...), and from project monitoring to writing articles and study reports. Regulatory submissions are made by the DRCI. Currently, the CRC supports 220 studies, of which 52% are academic promotion and 48% industrial promotion. Interventional studies represent 76% of the studies in progress at CRC in 2017.
* NASH : Non-alcoholic steatohepatitis.
Organization chart of the Clinical Research Center of the North Hospital Group of Lyon.
Center of Biological Resources (CRB) of the North Hospital Group
The CRB Nord is part of the Biological Resources Center of the Hospices Civil de Lyon (CRB-HCL) and has the required regulatory authorizations (DC-2011-1437 CRB HCL). The objective of the CRB-HCL is to provide local research teams and private or public partners with human biological samples and their associated clinical data.
This biobank is located within the North Hospital Group. It began its activity in 2007 with a collection of HIV samples (Human Immunodeficiency Virus) and also manages several PHRC (Hospital Clinical Research Program), 14 trials and ANRS cohorts and about fifty industrial trials. For some studies, the libraries of several cities in France are centralized on the CRB.
The CRB-GHNa obtained NF S 96-900 certification (French CRB standard based on ISO9001). All the CRB-HCL's collections use the online Tumorotek® software, whose access is secure. This software ensures the archiving of biological collections and facilitates their access for transversal clinical research, basic research, and industrial research.
The CRB has been working in partnership with the CRC (Clinical Research Center) of the GHN since its creation in 2011.
The CRB Nord is coordinated by Dr. Vinca Icard (Hospital Practitioner in Virology) and is composed of 5 people: 1 Hospital Practitioner (PH), 2 biological project managers and 2 technicians.
Pavillon R – Croix-Rousse Hospital, Lyon
Inserm-Cancer Research Center of Lyon (CRCL) teams
Team "Mechanisms of the pathogenesis of chronic hepatitis B and C and new antiviral strategies"
Hepatitis B and C viruses are responsible for chronic infections in nearly 600 million people around the world and promote the development of liver disease (steatosis and fibrosis) that can lead to cirrhosis and hepatocellular carcinoma (HCC). The main objectives of the team are to better understand the molecular mechanisms that allow the establishment and maintenance of persistent infections by hepatitis B and C viruses. A better understanding of these mechanisms should allow the development of new antiviral strategies (direct or by stimulation of the immune system) aimed at the eradication of viral infections and prevention (HCC) or regression (steatosis, fibrosis) associated pathologies.
The team is led by Professor Fabien Zoulim and is made of 51 people connected to Inserm, the Cancer Research Center of Lyon (CRCL), the University Claude Bernard Lyon 1 (UCBL), or the Hospices Civils de Lyon. The team brings together 12 researchers, 8 HDR (habilitation to direct research), 9 ITA staff (Engineer - Technician - Administrative) and 22 students (6 postdocs, 12 PhD students and 4 students in Master 2). The team is housed in the premises of Inserm Unit U1052 located in Lyon.
Team « Epigenetics and epigenomic of viro-induced hepatocellular carcinoma (EpiHep)
The EpiHep team studies the epigenetic changes that precede and accompany the development and progression of hepatocellular carcinoma occurring mainly but not exclusively in the course of chronic hepatitis B.
The EpiHep team is led by Prof. Massimo Levrero and brings together 9 people: 2 researchers, 2 ITAs, 3 postdocs and 2 PhD students. The EpiHep team shares the premises of the Inserm U1052 unit in Lyon with Prof. Fabien Zoulim's team.
Inserm U1052 / Cancer Research Center of Lyon (CRCL)
Teams at the Cancer Research Center of Lyon (CRCL) – Inserm U1052
Interactions between the different teams
Fondazione IRCC Ca’ Granda Ospedale Maggiore Policlinico – Université de Milan, Italie
Contact : Pr Pietro Lampertico, MD, PhD, Professeur associé de gastroentérologie, Chef du département de gastroentérologie et hépatologie de la Fondazione IRCC Ca’ Granda Ospedale Maggiore Policlinico
IRCCS Humanitas Clinical Institute, Milan, Italie
Contact : Pr Massimo Colombo, MD
Unité des maladies infectieuses et hépatologie, Laboratoire d’immunopathologie virale, université de Parme, Italie
Contact : Pr Carlo Ferrari, MD, PhD, directeur de l’unité des maladies infectieuses et hépatologie, Hôpital universitaire de Parme, Italie
Unité de gastroentérologie – université de Palerme, Italie
Contact : Pr Antonio Craxi, MD, Professeur de gastroentérologie à l’université de Palerme, directeur de gastroentérologie et hépatologie au sein du département académique de médecine interne
Hôpital de Rui Jin, Université Shanghai Jiao Tong, Ecole de Médecine, Chine
Contact : Pr Xinxin Zhang, MD, PhD, Professeur de maladies infectieuses, directeur du laboratoire de recherche de virologie clinique