News
Vous trouverez ci-dessous le lien vers la journée mondiale contre l'hépatite :
CRCL Lecture - Lundi 14 juin - 15h00
Nicole Gaudelli, Beam Therapeutics
“Adenine Base Editors : a journey from publication to the bedside.”
Connexion à la visioconférence :
https://zoom.us/j/99738828590?pwd=bUVhMXBjZk42L1AwVlZDNXFyU0ExZz09
ID : 997 3882 8590
Mot de passe : CRCL2021
Biosketch & selected references :
Nicole Gaudelli received her B.S. degree in biochemistry from Boston College in 2006 where she studied the structural and mechanistic underpinnings of neocarzinostatin biosynthesis and a non-heme iron oxygenase involved in vancomycin assembly. She earned her Ph. D. in chemistry from Johns Hopkins University where she studied monocyclic beta-lactam antibiotics and elucidated the mechanism through which they are biosynthesized. She completed her postdoctoral fellowship at Harvard University in the laboratory of Professor David R. Liu where she expanded the capabilities of base editing technology by inventing and creating the first adenine base editor (ABE) through 7 rounds of directed evolution and engineering. Both her doctoral and postdoctoral work culminated in prominent Nature publications in the fields of natural product chemistry and gene editing respectively. Nicole is an inventor on numerous base editing patents and is the Director and Head of the Gene Editing Technologies platform group at Beam Therapeutics where her team advances and engineers precision genetic medicines using base editors as well as other gene editing tools. Nicole is a recipient of the 2018 American Chemical Society's “Talented 12” award, recognized as a 2018 STAT News Wunderkind, a 2018 TEDMED Hive honoree, Genetic Engineering and Biotechnology News “Top 10 Under 40 of 2019”, BioSpace’s 2019 “10 Life Science Innovators Under 40 to Watch”, MIT’s 2019 Technology Reviews’ 35 Innovators Under 35, Business Insider’s 30 Under 40 in 2020, Fortune Magazine’s 40 Under 40 in Healthcare in 2020 and Enpoint News’s 20 Under 40 in biopharma in 2021.
1: Musunuru K, Chadwick AC, Mizoguchi T, Garcia SP, DeNizio JE, Reiss CW, Wang K, Iyer S, Dutta C, Clendaniel V, Amaonye M, Beach A, Berth K, Biswas S, Braun MC, Chen HM, Colace TV, Ganey JD, Gangopadhyay SA, Garrity R, Kasiewicz LN, avoie J, Madsen JA, Matsumoto Y, Mazzola AM, Nasrullah YS, Nneji J, Ren H, Sanjeev A, Shay M, Stahley MR, Fan SHY, Tam YK, Gaudelli NM, Ciaramella G, Stolz LE, Malyala P, Cheng CJ, Rajeev KG, Rohde E, Bellinger AM, Kathiresan S.
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
Nature. 2021 May;593(7859):429-434.
2: Yu Y, Leete TC, Born DA, Young L, Barrera LA, Lee SJ, Rees HA, Ciaramella G, Gaudelli NM.
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity.
Nat Commun. 2020 Apr 28;11(1):2052.
3: Gaudelli NM, Lam DK, Rees HA, Solá-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G.
Directed evolution of adenine base editors with increased activity and therapeutic application.
Nat Biotechnol. 2020Jul;38(7):892-900.
4: Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR.
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.
Nat Biotechnol. 2019 Jun;37(6):626-631.
5: Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR.
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.
Nature. 2017 Nov 23;551(7681):464-471.
Nous avons le plaisir de vous annoncer que la Journée d’Hépatologie et de Transplantation Hépatique aura lieu le jeudi 2 décembre 2021 sous l’égide de l’Institut d’Hépatologie de Lyon.
Merci de noter cette date et nous reviendrons vers vous prochainement avec le programme et les modalités d’inscription.
Flyer Journée d’Hépatologie et de Transplantation Hépatique
Congrès ILC - Ouverture d’appel à abstracts
https://easl.eu/event/the-international-liver-congress-2021/submit-your-abstract/
Hélène sur l'Everest
https://www.facebook.com/Helene-sur-lEverest-105698024496337
https://www.youtube.com/watch?v=TFPzyFwbcsk
Nous sommes heureux de partager avec vous cette formidable nouvelle: Hélène a atteint le sommet de l'Everest le 11/05/2021. Elle entame désormais la redescente avec prudence avec toute son équipe !
Offre d'emploi, Manager de Projet
Revue Tonic des HCL - Novembre 2020.
Journée mondiale contre l’hépatite 2020 : l’ANRS toujours engagée
Prévention de la transmission du virus de l'hépatite B de la mère à l'enfant : guidelines sur la prophylaxie antivirale pendant la grossesse
Nous vous annonçons la création d'une hotline Urgence Foie aux HCL !
Cliquer pour ouvrir la présentation : Urgence Foie HCL